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Original ArticleOpen Access
Clonidine for Smoking Cessation
Nana A 
,
Praditsuwan R
,
Praditsuwan R Clonidine was used to reduce withdrawal symptoms of nicotine and increase the success
rate of smoking cessation in the smoking cessation clinic of Siriraj Hospital. One hundred and
fourteen subjects enrolled in a double-blind, randomised, placebo-controlled trial. Subjects were
divided as clonidine group (n=58) with the mean age of 38 years and placebo group (n=56) with the
mean age of 33 years. Both groups received information about harmful effects of smoking as
well as behavioral modification protocol. The dose of clonidine used in this study was 300
microgram and the duration of the trial was 5 weeks. Both subject groups attended the clinic
weekly and received identical counselling. Clonidine did not reduce withdrawal symptoms of
nicotine when compared to the placebo and the success rate of smoking cessation at the end of the
5 weeks' period was identical between the two groups (clonidine 50%; placebo 48%, p>0.05). No
significant side effects of clonidine were found. There was no correlation between background
educational level, income, amount of cigarettes smoked per day and the success rate in both
groups. In conclusion, clonidine did not show any beneficial effect on smoking cessation.
rate of smoking cessation in the smoking cessation clinic of Siriraj Hospital. One hundred and
fourteen subjects enrolled in a double-blind, randomised, placebo-controlled trial. Subjects were
divided as clonidine group (n=58) with the mean age of 38 years and placebo group (n=56) with the
mean age of 33 years. Both groups received information about harmful effects of smoking as
well as behavioral modification protocol. The dose of clonidine used in this study was 300
microgram and the duration of the trial was 5 weeks. Both subject groups attended the clinic
weekly and received identical counselling. Clonidine did not reduce withdrawal symptoms of
nicotine when compared to the placebo and the success rate of smoking cessation at the end of the
5 weeks' period was identical between the two groups (clonidine 50%; placebo 48%, p>0.05). No
significant side effects of clonidine were found. There was no correlation between background
educational level, income, amount of cigarettes smoked per day and the success rate in both
groups. In conclusion, clonidine did not show any beneficial effect on smoking cessation.
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