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Original ArticleOpen Access
Association of mdrl Gene Expression with Other Prognostic Factors and Clinical Outcome in Human Breast Cancer
Punyammalee B 
,
Manoromana S ,
Purisa W ,
Chariyalertsak S ,
Rerkamnuaychok B
,
Manoromana S ,
Purisa W ,
Chariyalertsak S ,
Rerkamnuaychok B Multidrug resistance of cancer (CA) is one of a major problems in CA chemotherapy
that is frequently associated with the expression of P-glycoprotein (P-gp) encoded by mdrl genes.
However, the controversial results exist regarding to the significance of mdrl gene expression on
clinical drug resistance to chemotherapy of breast CA cells. Recent evidence reported a strong
correlation between the increased P-gp levels and the prognosis in advanced breast CA. The current
study investigated whether mdrl gene expression has any impact on prognosis and response to
chemotherapy in breast CA patients. We determined mdrl expression in 127 primary and 8
locally relapsed breast CA using a sensitive, specific and quantitative technique based on a RTPCR
and Southern blot hybridization detection by non-radioactive labelled-probe. In patients
with primary breast CA, mdrl expression were negative (mdrl-ve), low (
that is frequently associated with the expression of P-glycoprotein (P-gp) encoded by mdrl genes.
However, the controversial results exist regarding to the significance of mdrl gene expression on
clinical drug resistance to chemotherapy of breast CA cells. Recent evidence reported a strong
correlation between the increased P-gp levels and the prognosis in advanced breast CA. The current
study investigated whether mdrl gene expression has any impact on prognosis and response to
chemotherapy in breast CA patients. We determined mdrl expression in 127 primary and 8
locally relapsed breast CA using a sensitive, specific and quantitative technique based on a RTPCR
and Southern blot hybridization detection by non-radioactive labelled-probe. In patients
with primary breast CA, mdrl expression were negative (mdrl-ve), low (
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