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Original ArticleOpen Access
Accuracy of Fine Needle Aspiration Cytology in the Evaluation of Peripheral Lymphadenopathy
Mostafa MG 
,
Chiemchanya S ,
Srivannaboon S ,
Nitiyanant P
,
Chiemchanya S ,
Srivannaboon S ,
Nitiyanant P We conducted an audit of the lymph node aspirates received from January 1996 to
December 1996 of 541 patients sent to the Cytology Division, Department of Pathology, Ramathibodi
Hospital by their clinicians. The aim of this retrospective study was to determine the
pattern of diseases that commonly present with peripheral lymphadenopathy and to evaluate the
accuracy of Fine Needle Aspiration Cytology (FNAC) in the diagnosis of lymph node diseases.
An excisional biopsy sample of lymph node was available in 233 (43%) cases for comparison to
the histopathology. The predominant lesion was benign which included necrotizing granulomatous
lymphadenitis (NGL), reactive changes (RC) and suppurative lymphadenitis (SL). The
predominant malignant lesion was metastatic squamous cell carcinoma. The accuracy for NGL,
SL and RC were 69 per cent, 75 per cent and 95 per cent, respectively. The accuracy for metastatic
disease was 97 per cent. The specificity and sensitivity of FNAC were 99 per cent and 94 per
cent, respectively. An excisional biopsy should be done in case of doubt to clarify the pattern of
RC.
December 1996 of 541 patients sent to the Cytology Division, Department of Pathology, Ramathibodi
Hospital by their clinicians. The aim of this retrospective study was to determine the
pattern of diseases that commonly present with peripheral lymphadenopathy and to evaluate the
accuracy of Fine Needle Aspiration Cytology (FNAC) in the diagnosis of lymph node diseases.
An excisional biopsy sample of lymph node was available in 233 (43%) cases for comparison to
the histopathology. The predominant lesion was benign which included necrotizing granulomatous
lymphadenitis (NGL), reactive changes (RC) and suppurative lymphadenitis (SL). The
predominant malignant lesion was metastatic squamous cell carcinoma. The accuracy for NGL,
SL and RC were 69 per cent, 75 per cent and 95 per cent, respectively. The accuracy for metastatic
disease was 97 per cent. The specificity and sensitivity of FNAC were 99 per cent and 94 per
cent, respectively. An excisional biopsy should be done in case of doubt to clarify the pattern of
RC.
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