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Original ArticleOpen Access
Linac Based Radiosurgery (X-knife) for Brain Metastases
pattaranutaporn P 
,
Wannissorn J ,
Chansilpa Y ,
Kakanaporn C ,
Onnomdee K ,
Mungkung N
,
Wannissorn J ,
Chansilpa Y ,
Kakanaporn C ,
Onnomdee K ,
Mungkung N Linac based stereotactic radiosurgery by X-knife, technique that permits the precise delivery
of a high dose of radiation from 6 MV linear accelerator to intracranial target(s) while sparing
the normal tissue, has been used as an alternative treatment for brain metastasis. Five patients
with 9 metastatic lesions were treated with this technique. The radiation dose was 15-25 Gy with
the 75-80 per cent isodose line encompassing the enhancing tumor according to the tumor volume,
site and previous treatment. All metastatic lesions were evaluated at 4 weeks after treatment, there
were 2 CR, 4 PR and 3 remained unchanged. The result showed a very distinct clear radiation effect
margin between the target and normal tissue. The patient could tolerate the treatment procedure
well without any complications inherent to the technique. All patients with neurological symptoms
had a satisfactory recuperation. Radiosurgery with X-knife is an effective and safe therapy for
brain metastases. It can be applied as a primary treatment, as a booster in combination with whole
brain irradiation, or as treatment for patients with relapse in a previous irradiated area.
of a high dose of radiation from 6 MV linear accelerator to intracranial target(s) while sparing
the normal tissue, has been used as an alternative treatment for brain metastasis. Five patients
with 9 metastatic lesions were treated with this technique. The radiation dose was 15-25 Gy with
the 75-80 per cent isodose line encompassing the enhancing tumor according to the tumor volume,
site and previous treatment. All metastatic lesions were evaluated at 4 weeks after treatment, there
were 2 CR, 4 PR and 3 remained unchanged. The result showed a very distinct clear radiation effect
margin between the target and normal tissue. The patient could tolerate the treatment procedure
well without any complications inherent to the technique. All patients with neurological symptoms
had a satisfactory recuperation. Radiosurgery with X-knife is an effective and safe therapy for
brain metastases. It can be applied as a primary treatment, as a booster in combination with whole
brain irradiation, or as treatment for patients with relapse in a previous irradiated area.
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