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Original ArticleOpen Access
Plasticity of the Motor Cortex in Patients with Brain Tumors and Arteriovenous Malformations: A Functional MR Study
Tuntiyatorn L 
,
Wuttiplakorn L ,
Laohawiriyakamol K
,
Wuttiplakorn L ,
Laohawiriyakamol K Objective: Test the hypothesis about the potential role of functional MRI (fMRI) to evaluate the plasticity of the cortical motorareas in patients with brains tumors and brain arteriovenous malformations (AVMs) and measurement of the lesion-to-fMRIactivation distance for predicting risk of new motor deficit after surgery.
Material and Method: This was a retrospective study. The present study population enrolled eight patients with motor cortexlesions. Cortical motor representations were mapped in these patients harboring tumor or AVMs occupying the region ofprimary motor cortex (M1). Five patients had known diagnosis of primary brain tumor including glioblastoma multiforme,(n = 1), diffuse astrocytoma (n = 2), dysembryoplastic neuroepithelial tumor (DNET) (n = 1) and unknown pathology(n = 1). Three patients had known diagnosis of brain AVMs. Three patients showed hemiparesis at the time of presentation.Focal/generalized seizure or headache was present in the remaining patients. Simple movements of both hands wereperformed. Localization of the activation in the affected hemisphere was compared with that in the unaffected hemisphere andevaluated with respect to the normal M1 somatotopic organization. Distance between the location of the fMRI activation (M1)and margin of the lesion was recorded.
Results: Cortical activation was found in two patterns: 1) functional displacement within affected M1 independent of thestructural distortion induced by the tumor or AVMs (n = 7) and 2) presence of activation within the non-primary motor cortexwithout activation in the affected or unaffected M1 (n = 1).
Conclusion: Brain tumor or AVMs led to reorganization within the somatotopic affected M1 and can expand into nonprimarymotor cortex area. Distortion of the anatomy alone by the space-taking lesion did not influence the location of thereorganized cortex. No particular type of reorganization pattern could be predicted. fMRI could be localized reorganizedcortex and was found to be a useful tool to assess the lesion-to-activation distance for predicting risk of new motor deficit aftersurgery. The present study thus emphasizes the importance of considering additional fMRI with structural MRI to evaluateindividual differences in cortical plasticity for treatment planning, particularly in the neurosurgical procedure.
Keywords: Plasticity, Motor cortex, Brain tumors, Arteriovenous malformations, Functional MR
Material and Method: This was a retrospective study. The present study population enrolled eight patients with motor cortexlesions. Cortical motor representations were mapped in these patients harboring tumor or AVMs occupying the region ofprimary motor cortex (M1). Five patients had known diagnosis of primary brain tumor including glioblastoma multiforme,(n = 1), diffuse astrocytoma (n = 2), dysembryoplastic neuroepithelial tumor (DNET) (n = 1) and unknown pathology(n = 1). Three patients had known diagnosis of brain AVMs. Three patients showed hemiparesis at the time of presentation.Focal/generalized seizure or headache was present in the remaining patients. Simple movements of both hands wereperformed. Localization of the activation in the affected hemisphere was compared with that in the unaffected hemisphere andevaluated with respect to the normal M1 somatotopic organization. Distance between the location of the fMRI activation (M1)and margin of the lesion was recorded.
Results: Cortical activation was found in two patterns: 1) functional displacement within affected M1 independent of thestructural distortion induced by the tumor or AVMs (n = 7) and 2) presence of activation within the non-primary motor cortexwithout activation in the affected or unaffected M1 (n = 1).
Conclusion: Brain tumor or AVMs led to reorganization within the somatotopic affected M1 and can expand into nonprimarymotor cortex area. Distortion of the anatomy alone by the space-taking lesion did not influence the location of thereorganized cortex. No particular type of reorganization pattern could be predicted. fMRI could be localized reorganizedcortex and was found to be a useful tool to assess the lesion-to-activation distance for predicting risk of new motor deficit aftersurgery. The present study thus emphasizes the importance of considering additional fMRI with structural MRI to evaluateindividual differences in cortical plasticity for treatment planning, particularly in the neurosurgical procedure.
Keywords: Plasticity, Motor cortex, Brain tumors, Arteriovenous malformations, Functional MR
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