Objective: To determine the prevalence and associated factors of stress and quality of life in office workers in Bangkok Metropolitan Administration.

Materials and Methods: This is a questionnaire based descriptive study. Questionnaires consisted of 4 parts: personal information, Suanprung stress test, WHOQOL-BREF-THAI (26 items) and Thai-job content questionnaire. The prevalence and association were calculated by Chi-square test.

Results: A total of 495 participants were included. Of these, 43.8% experienced abnormal stress and 62.2% had poor quality of life. From multivariate analysis, significant risk factors of abnormal stress included alcoholic consumption, sitting work > 7 hours per day, computer work sitting > 5 hours per day, poor quality of life, high physical job demand and hazard at work. The risk factors of poor quality of life were bachelor’s degree, single, absence of exercise, abnormal stress and high physical job demand. One protective factor for poor quality of life was high job control.      

Conclusion: About half of office workers in Bangkok Metropolitan Administration had abnormal stress and poor quality of life. The present results could serve as a guideline to establish solution for alleviating stress and improving quality of life for these group of people.