Objective: This study aimed to evaluate the efficacy of various treatment modalities for advanced buccal mucosa cancer.

Materials and Methods: This was a retrospective study conducted at the Division of Plastic and Reconstructive Surgery in the Department of Surgery at Khon Kaen University's Faculty of Medicine (Khon Kaen, Thailand). The study period was between 2006 and 2010. The inclusion criterion was diagnosis with buccal mucosa cancer at any stage.

Results: There were 101 patients with buccal mucosa cancer who met the study criteria. A majority of the patients were elderly, with 40.6% being70-79 years old and 35.64% being 60-69 years old. Eighty-one (80.2%) patients were female and 20 were male. The overall median survival time for all stages was 12.5 months, with a range of 0.6-146.6 months. The survival outcomes ofcombination therapy consisting ofsurgical resection and chemoradiation did not differ from those of surgery plus radiotherapy.

Conclusion: A combination therapy for advanced buccal mucosa cancer consisting of surgical resection and chemoradiation did not differ from surgery plus radiotherapy in terms of survival.