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Original ArticleOpen Access
Modification of Platelet Shape Change Parameter by Modified Phospholipids in Oxidized LDL
Sutipornpalangkul W 
,
Unchen S ,
Sanvarinda Y ,
Chantharaksri U
,
Unchen S ,
Sanvarinda Y ,
Chantharaksri U Background: It is believed that the oxidatively modified lipoproteins play a critical role in activating platelets
and is a contributing factor in the etiology of a number of cardiovascular-related diseases.
Objective: Identify the active component(s) of oxidized LDL that initiated shape change in plasma-free human
platelets prepared by a gel filtration method.
Material and Method: Shape change parameter of platelets was monitored following exposure platelets to
LDL, copper sulfate-oxidized LDL, and different types of lipids extracted of the corresponding LDL.
Results: Oxidized LDL, but not native LDL, increased the shape-change parameter in a concentration-dependent
manner. Specifically, phosphatidyl serine from oxidized LDL was responsible for this effect.
Conclusion: Oxidized phospholipids generated during the oxidative modification of LDL are likely to be the
active components responsible for changes in platelet function.
Keywords: Oxidized LDL, Platelet shape change, Phospholipids, Atherosclerosis
and is a contributing factor in the etiology of a number of cardiovascular-related diseases.
Objective: Identify the active component(s) of oxidized LDL that initiated shape change in plasma-free human
platelets prepared by a gel filtration method.
Material and Method: Shape change parameter of platelets was monitored following exposure platelets to
LDL, copper sulfate-oxidized LDL, and different types of lipids extracted of the corresponding LDL.
Results: Oxidized LDL, but not native LDL, increased the shape-change parameter in a concentration-dependent
manner. Specifically, phosphatidyl serine from oxidized LDL was responsible for this effect.
Conclusion: Oxidized phospholipids generated during the oxidative modification of LDL are likely to be the
active components responsible for changes in platelet function.
Keywords: Oxidized LDL, Platelet shape change, Phospholipids, Atherosclerosis
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