Objective: To study the efficacy of intra-operative TXA regimen on reducing blood loss and blood transfusion in TKA.

Material and Method: In this retrospective comparative study, 60 patients were divided into two groups. Patients in Group 1 were given 10 mg/kg intravenous TXA 10 minutes before inflation of the tourniquet and again immediately after deflation of the tourniquet. Patients in Group 2 did not receive TXA. Blood loss, blood transfusion, and complications were compared between the two groups.

Results: Study findings revealed that intra-operative TXA regimen could significantly reduce drained blood (660±117.8 ml vs. 1,141.7±157.9 ml, p<0.001), decreasing hemoglobin at 12 hours (1.8±0.3 g/dL vs. 2.5±0.5 g/dL, p<0.001) and blood transfusion (26.7% vs. 80.0%, p<0.001) with no increase in procedure-associated complications.

Conclusion: Intra-operative TXA regimen has the efficacy on reducing blood loss and blood transfusion requirement in TKA without potential risk of complications.

Keywords: Tranexamic acid, Knee arthroplasty, Blood loss, Transfusion