The authors present a case of an 80-year-old man, non-diabetic, who attempted suicide by injecting
himself subcutaneously with 10,000 units of Humulin R and 6,000 units of Humulin N. Administration of
dextrose intravenously was required for 13 days to maintain the capillary blood glucose within the range of
100-180 mg/dl. Hyponatremia, hypokalemia, hypophosphatemia, and elevated liver enzymes were also seen
after massive insulin injection. Glucose requirement index was established to demonstrate the trend of glucose
requirement during hospitalization. He recovered completely without any complication after monitoring
blood glucose and titrating intravenous glucose carefully for two weeks. Current literature about how to
manage insulin overdose was reviewed in the present article.

Keywords: Insulin overdose, Complications, Glucose requirement index