Views: 1,322 | Downloads:
23
| Responses: 0
| XML | Respond to this article | Alert & updates | Request permissions | Email to a friend |
Original ArticleOpen Access
Prevalence of Hyperhomocysteinemia in Normal Healthy Thai Subjects
Leowattana W 
,
Mahanonda N ,
Bhuripanyo K ,
Pokum S
,
Mahanonda N ,
Bhuripanyo K ,
Pokum S NITHI MAHANONDA, M.D.**,
SASIKANT POKUM, B.Sc.*
The concentration of circulating total homocysteine is a sensitive marker of inadequate
folate and vitamin B12 status. The elevations of plasma homocysteine concentration are associated
with an increased risk of vascular disease. The primary goals of this study were to identify plasma
homocysteine concentrations in Thai residents and to test for differences in homocysteine levels
among sex and age categories. The authors measured plasma total homocysteine concentrations in
3,345 Shinawatra employees (1,133 males, 2,212 females aged between 20-65 years) by using fluo-
rescence polarization immunoassay (FPIA) method. The mean plasma homocysteine concentrations
of males and females were 11.495 and 8.547 Jlmol/L respectively. Plasma homocysteine concentra-
tions were significantly lower in females than in males (p
<
0.0001). The age-specific plasma
homocysteine levels were lower in females than in males for each group, but the levels of each
group was not significantly different both in males and females. When more than 12 Jlmol/L was
used as the cut-off value, it was found that 33.6 per cent of males and 6.69 per cent of females
were classified as hyperhomocysteinemia subjects. The authors concluded that the prevalence of
hyperhomocysteinemia in Thai males is more common than in females. Further investigation should
be done to clarify the association between serum folate, vitamin B 12, vitamin B6 concentrations and
plasma homocysteine concentration.
Key word : Homocysteine, Folate, Vitamin B 12, Prevalence, Hyperhomocysteinemia
SASIKANT POKUM, B.Sc.*
The concentration of circulating total homocysteine is a sensitive marker of inadequate
folate and vitamin B12 status. The elevations of plasma homocysteine concentration are associated
with an increased risk of vascular disease. The primary goals of this study were to identify plasma
homocysteine concentrations in Thai residents and to test for differences in homocysteine levels
among sex and age categories. The authors measured plasma total homocysteine concentrations in
3,345 Shinawatra employees (1,133 males, 2,212 females aged between 20-65 years) by using fluo-
rescence polarization immunoassay (FPIA) method. The mean plasma homocysteine concentrations
of males and females were 11.495 and 8.547 Jlmol/L respectively. Plasma homocysteine concentra-
tions were significantly lower in females than in males (p
<
0.0001). The age-specific plasma
homocysteine levels were lower in females than in males for each group, but the levels of each
group was not significantly different both in males and females. When more than 12 Jlmol/L was
used as the cut-off value, it was found that 33.6 per cent of males and 6.69 per cent of females
were classified as hyperhomocysteinemia subjects. The authors concluded that the prevalence of
hyperhomocysteinemia in Thai males is more common than in females. Further investigation should
be done to clarify the association between serum folate, vitamin B 12, vitamin B6 concentrations and
plasma homocysteine concentration.
Key word : Homocysteine, Folate, Vitamin B 12, Prevalence, Hyperhomocysteinemia
Download:
PDF