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Original ArticleOpen Access
Estradiol and Follicle-stimulating Hormone Levels in Oophorectomized Women using Vaginal Estrogen
Taechakraichana N 
,
lntraragsakul A ,
Panyakhamlerd K ,
Numchaisrika r ,
Limpaphayom K
,
lntraragsakul A ,
Panyakhamlerd K ,
Numchaisrika r ,
Limpaphayom K To assess the changing estradiol (E2) and follicle-stimulating hormone (FSH) level in
oophorectomized women using vaginal estrogen. Serum estradiol and FSH were evaluated in 32
oophorectomized women using a daily dose of 2 g base of 1.25 mg vaginal conjugated equine
estrogen (CEE) cream. The blood sample for hormone assay was collected 8-10 hours from the time
of vaginal application. E2 and FSH levels were measured in the serum sample before and after
commencing the study at 4, 8 and 12 weeks using the time-resolved fluoroimmunoassay method.
Serum estradiol significantly increased from baseline value at 4, 8 and 12 weeks. (Mean±SD of E2
value at 0, 4, 8, 12 weeks : 9.97±12.13, 249.83±170.46, 299.38±190.65, 322.82±218.31 pmol/L,
respectively, P
oophorectomized women using vaginal estrogen. Serum estradiol and FSH were evaluated in 32
oophorectomized women using a daily dose of 2 g base of 1.25 mg vaginal conjugated equine
estrogen (CEE) cream. The blood sample for hormone assay was collected 8-10 hours from the time
of vaginal application. E2 and FSH levels were measured in the serum sample before and after
commencing the study at 4, 8 and 12 weeks using the time-resolved fluoroimmunoassay method.
Serum estradiol significantly increased from baseline value at 4, 8 and 12 weeks. (Mean±SD of E2
value at 0, 4, 8, 12 weeks : 9.97±12.13, 249.83±170.46, 299.38±190.65, 322.82±218.31 pmol/L,
respectively, P
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