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Original ArticleOpen Access
Epidemiology of Sepsis in Siriraj Hospital 2007
Angkasekwinai N 
,
Rattanaumpawan P ,
Thamlikitkul V
,
Rattanaumpawan P ,
Thamlikitkul V Background: Sepsis remains a major health burden, and there is limited epidemiological report of sepsis in
Thailand.
Objective: To determine the epidemiology, treatments, clinical courses and outcomes of sepsis patients.
Material and Method: All sepsis patients in medical wards at Siriraj Hospital were recruited from February
1 to July 31, 2007. The information from patients’ medical records were retrieved and analyzed.
Results: From 3,451 patients, 201 (5.8%) were diagnosed as sepsis, and 38.8% of these developed septic
shock. Among sepsis patients, 62.2% were community acquired, 40.8% had bacteremia, and gram negative
bacteria were the common pathogen (51.7%). Appropriate antibiotics were given within 6 hours in 39%.
Goal-directed therapy was achieved in only 11.5%. The mortality among sepsis and septic shock patients was
34.3% and 52.6%, respectively (p = 0.008). Risk factors for hospital mortality included higher maximum
SOFA score, hospital-acquired infection, central nervous system dysfunction and receiving antibiotics after 6
hours of onset of sepsis.
Conclusion: Sepsis is still common and has contributed to high mortality. Goal directed therapy and
appropriate antibiotics given within 6 hours might improve the outcome.
Keywords: Sepsis, Shock, Septic
Thailand.
Objective: To determine the epidemiology, treatments, clinical courses and outcomes of sepsis patients.
Material and Method: All sepsis patients in medical wards at Siriraj Hospital were recruited from February
1 to July 31, 2007. The information from patients’ medical records were retrieved and analyzed.
Results: From 3,451 patients, 201 (5.8%) were diagnosed as sepsis, and 38.8% of these developed septic
shock. Among sepsis patients, 62.2% were community acquired, 40.8% had bacteremia, and gram negative
bacteria were the common pathogen (51.7%). Appropriate antibiotics were given within 6 hours in 39%.
Goal-directed therapy was achieved in only 11.5%. The mortality among sepsis and septic shock patients was
34.3% and 52.6%, respectively (p = 0.008). Risk factors for hospital mortality included higher maximum
SOFA score, hospital-acquired infection, central nervous system dysfunction and receiving antibiotics after 6
hours of onset of sepsis.
Conclusion: Sepsis is still common and has contributed to high mortality. Goal directed therapy and
appropriate antibiotics given within 6 hours might improve the outcome.
Keywords: Sepsis, Shock, Septic
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