Background: The promotion of breastfeeding is beneficial to infants with cleft lip and palate (CLP). Nursing practice guidelines are important for the Nurses team to give practice for mothers with infants CLP.

Objective:To develop a nursing practice to promote breastfeeding for infants with CLP in Srinagarind Hospital.

Materials and Methods: This descriptive research was conducted to obtain recommended guideline to promote breastfeeding for infants with CLP, was carried out for four months. The literature was collected from nursing and medical databases, CINAHL, PubMed, the Cochrane Library, THAIJO, and Google Scholar by using PICO from. In order to evaluate the level of reliability of the evidence or literature as well as the introduction of the practice, the choices were based on the selection of standard criteria and validity test conducted by 4 experts.

Results:A total of  140 documents were accessible in the databases, but eight documents were synthesized into three key practical guidelines for breastfeeding  infants with CLP, namely: (1) the types and degrees of severity of the cleft palates conditions, as well as disability and the evaluation of the mother after parturition, including her mental state and need for assistance; (2)the assistance from the nurses, who give the information regarding how to correctly hold the infant when breastfeeding and how to the evaluate the infant’s weight; and (3) the plans to be made before discharge and the instructions to be given in the correct techniques to get and store milk from the mother’s breasts to be used later.

Conclusion: The three practices of breastfeeding for infants with CLP: (1) the evaluation of the infants and the mothers, (2) the assistance received from the nurse, and (3) the proper preparation before discharge, help the nurse team as guideline to practice and take care the Infants with CLP.